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Excessive iron accumulation in mitochondria causes oxidative stress, generating harmful free radicals that damage DNA, proteins, and lipids, ultimately impairing cardiac function ( / mice exhibited increased expression of mitoferrin 2 (Mfrn2), an iron transporter in the inner mitochondrial membrane

Sci Rep 5:110

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As an example, the crystal violet or supravital blood stain of an infant with significant hyperbilirubinemia who was G6PD-deficient did not show the presence of Heinz bodies (Figure 2)

That doesn't mean enjoying an occasional glass of wine is inherently problematic, but it does help explain why the body relies on antioxidant systems like glutathione to help process and recover from these exposures